Disse fremstilles ved industriell behandling av ekstrakter fra valmue eller kjemisk produksjon uavhengig av opiumråstoff, for eksempel oksykodon og fentanyl.Biholebetennelse går vanlegvis in excess of utan behandling. Reseptfrie smertestillande som paracetamol eller ibuprofen kan lindre smertene.Andre smertestillende midler Det finnes mange grupp
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